Future farming must face and overcome two main constraints: i) pursuing the goal of producing more and of higher quality, on increasingly smaller arable lands, using less inputs, e.g. water, energy, fertilizers, pesticides, etc.; ii) sustaining the socioeconomic function of agriculture systems, and their bioeconomy. Our Spoke - Multifunctional and Resilient Agriculture and Forestry Systems for the Mitigation of Climate Change Risks - is undertaking two main actions: i) at crop level, exploiting next-generation genotyping/phenotyping platforms for the selection of cultivated varieties tolerant to biotic and resilient to abiotic stresses, ensuring greater unit yields (“more with less” principle); ii) at field level, finding the best technology solutions with the aim of increasing the use efficiency of inputs according to the “do no significant harm” principle.